- Release of chemicals: When inflammation occurs, the body releases chemicals that can irritate nerve endings. These chemicals include bradykinin, histamine, and prostaglandins.
- Increased pressure: Inflammation can cause swelling, which can put pressure on nerve endings. This pressure can cause pain.
- Change in nerve function: Inflammation can also change the way that nerves function. This can make nerves more sensitive to pain and can also cause nerves to fire more easily.
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